I was thinking about something you mentioned before. Maybe in another thread that the Uzumaki have the sage's body, Naruto in RM, and the sage's eyes, Negato.

Would it be possible that the Uzumaki are either the sage's original clan. They have advanced knowledge of sealing techs, masses of chakra and durable bodies.

Or for the same reasons they could have resulted from the mixing of Uchiha and Senju.